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Primary and Specific Anamnestic Antibody Responses of Rabbits to Heterologous Serum Protein Antigens¹

From the Pathology Department, University of Pittsburgh School of Medicine, Pittsburgh, Pa.

Abstract

In the primary and anamnestic antibody responses to heterologous serum protein antigens rapid antibody synthesis ceases with or shortly after the disappearance of detectable antigen. In the primary response there was no conclusive evidence of continued antibody production after the disappearance of antigen. In the anamnestic responses, however, antibody continued to be produced at a low level for more than 6 months after antigen could no longer be detected.

Footnotes

¹ This study was supported by Atomic Energy Commission contract No. AT(30-1)-1205.

This is reprint No. 28 of the Pathology Department, University of Pittsburgh School of Medicine.