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Studies on Chick-Embryo-Adapted-Rabies Virus

VI. Further Changes in Pathogenic Properties Following Prolonged Cultivation in the Developing Chick Embryo

From Viral and Rickettsial Research, Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York

Abstract

After prolonged cultivation in the developing chick embryo the Flury strain of rabies virus lost its pathogenic properties for mice 14 days of age or older when injected intracerebrally. Suckling mice still remained fully susceptible. Dogs and rabbits were fully resistant to intracerebral inoculation of the virus, whereas rhesus monkeys were found to be almost as susceptible as baby mice.

Results of titrations of the virus in hamsters and guinea-pigs indicated the virus preparation was not homogeneous. Experiments are described in which different segments of the viral population were separated and analyzed. The existence of different forms of virus in different stages of adaptation is discussed.