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Production of Pulmonary Lesions by Influenza Viruses in Immunized Mice¹

From The Department of Preventive Medicine and of Medicine, School of Medicine, Western Reserve University, and the University Hospitals, Cleveland, Ohio

Abstract

Influenza viruses produced severe pulmonary lesions in mice immunized by intraperitoneal injections of the homologous agent. With inocula of 10^8.3 E.I.D. of CAM virus, pneumonia resulted which was as severe as in control mice. Immunized mice challenged with only 10^7.5 E.I.D. of influenza A or B virus initially developed lesions to the same extent as control animals, but maximum consolidation did not result. Although some viral multiplication probably occurred, it was postulated that it was the original quantity of virus inoculated which caused the lesions in immunized mice.

Footnotes

¹ This investigation was conducted under the sponsorship of the Commission on Acute Respiratory Diseases, Armed Forces Epidemiological Board, and was supported in part by the Office of The Surgeon General, Department of the Army, and by grants from the Brush Foundation and Mr. Philip R. Mather.