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Interference between Influenza and Equine Encephalitis Viruses in Tissue Culture¹

From the Department of Epidemiology, Harvard University School of Public Health, Boston, Massachusetts

Abstract

Modern tissue culture methods are suited to investigation of the interference phenomenon and Schlesinger (1) has sought explanation of interference between influenza (Lee strain) and eastern equine encephalitis viruses by studying the heat-stable receptor-like inhibitor of hemagglutination (VHI) by Lee virus. Infection with influenza virus was associated with progressive decrease in the amount of VHI extractable from minced chorio-allantoic membrane of chick embryos in tissue culture. Eastern equine encephalitis virus exerted no detectable effect on the VHI, and multiplied to full titre in tissue which had been depleted of all detectable VHI by enzymatic action. Other studies of virus interference in tissue culture employed strains of influenza (4), yellow fever (5), and certain encephalitis viruses (6).

Although the mechanisms of interference remain obscure the site is probably at the cellular level. Since relatively few cell types are involved, selected factors can be satisfactorily controlled; and observations on the developmental cycle and metabolism of the virus can be quantitated (2, 3).

Footnotes

¹ Supported in part by the Rockefeller Foundation.