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A Preliminary Report on the Purification of Foot-and-Mouth Disease Virus by Serological Methods

From the State Veterinary Institute for Virus Research, Lindholm, pr Kalvehave, Denmark, and the United States Bureau of Animal Industry, Washington, D. C.

Abstract

Repeated injections of a fraction from normal bovine tongue epithelium into rabbits elicited the production of precipitins. It was observed that most of the infectivity of purified virus preparations was also precipitated by the antiserum to normal bovine tissue. Quantitative precipitin tests indicated that at least 90% of the most highly purified virus preparation tested consisted of material serologically indistinguishable from normal host tissue. Virus produced in guinea pigs did not react with the antiserum. Although mixtures of normal bovine tissue antigen and guinea pig virus gave comparable serological precipitates, most of the infectivity of the guinea pig virus remained in the supernatant serum. The results suggest that foot-and-mouth disease virus may possess certain serological characteristics of the host in which it was produced.

Footnotes

^* Present address is Naval Biological Laboratory, Naval Supply Center, Oakland 4, California.