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The Effect of the Injection of Tetanus Toxin into the Central Nervous System of Rabbits¹

From the Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

Abstract

Tetanus toxin injected into the medulla oblongata of rabbits is approximately 1000 times as effective (measured by the period of survival) as toxin injected intravenously. The effectiveness of the injected toxin is progressively less as the following sites are employed—lumbar cord; cerebrospinal fluid and cerebral hemisphere (approximately equal); blood stream and gastrocnemius muscle.

Footnotes

¹ A preliminary account of some of this work was reported in Fed. Proc. 10: 348, 1951.

² Present address: Department of Pathology, Guy's Hospital Medical School, London, England.

³ This work was carried out while the author held a Rockefeller Foundation Fellowship.