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The Molecular Weight of an Antigen-Antibody Complex¹

Army Medical Service Graduate School, Walter Reed Army Medical Center, Washington, D. C.

Abstract

For the first time, so far as is known, the theory of Neurath has been applied experimentally to the determination of the diffusion coefficient of one component of a binary mixture in the presence of the other.

The molecular weight of the saturated human albumin, horse anti-human serum albumin complex has been determined in the presence of antigen. The molecular weight so determined is consistent with previous findings that this antibody has a valence of two.

In both the serum albumin and egg albumin systems the horse-antibody-containing complex has a significantly higher sedimentation constant than the corresponding complex containing rabbit antibody.

The possible relationship of this finding to the distribution of combining sites on the antibody molecule is discussed.

Footnotes

¹ A brief report of this paper was given at the second International Biochemical Congress, Paris, July 24, 1952.