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Antibody Formation in Vitro by Haemopoietic Organs after Subcutaneous and Intravenous Immunization¹

From the Department of Histology, University of Groningen, The Netherlands

Abstract

Fragments of spleen, bone marrow, liver, thymus and lymph nodes of rabbits immunized with paratyphoid B vaccine were cultivated in roller tubes for 24 hours.

Antibody production was demonstrated in the red and white pulp of the spleen, and in the bone marrow and lymph nodes, but in cultures of thymus and liver no antibody production was found.

With the technique used, the red pulp of the spleen was found to play the major part in antibody formation, both after subcutaneous and after intravenous immunization.

Footnotes

¹ This investigation was supported by a grant from the "Nederlandse Organisatie voor Zuiver Wetenschappelijk Onderzoek".

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