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In Vitro Action of Sulfur Mustard and Chloroethylamine Derivatives upon Antigenicity of Influenza A (PR8) Virus¹

From the Department of Bacteriology, University of California, Berkeley, California

Abstract

1. Immunization of mice with mustard-treated vaccines evoked the production of antibodies as demonstrated in vivo by their acquired resistance to intranasal administrations of active virus, by the in vitro neutralization of the infective and toxic components of virus and by the fixation of complement in the presence of specific antigen.

2. There were no marked differences between the antigenicity of sulfur and cyclo mustardtreated virus, but these were definitely inferior to the immunizing quality of native virus, a condition particularly noticeable upon reduction of the viral concentration of the vaccines.

3. The injection of mustard-virus suspensions into mice failed to cause any suppression of antibody production by the host.

Footnotes

¹ This work was aided by a grant from the Research Committee of the University of California.