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Studies on the Bactericidal Reaction¹

I. Bactericidal Action of Normal Sera Against a Strain of Salmonella Typhosa

From the Department of Bacteriology and Immunology, Washington University School of Medicine, St. Louis, Missouri

Abstract

Sera from guinea pigs and rabbits of normal stock contain relatively thermostable antibodies which mediate the killing of apparently S-state cells of Salmonella typhosa by complement. The "normal" bactericidins appear to be specific for antigenic factors IX and XII, which are characteristic for the surface of S-state S. typhosa cells. An additional factor, present in all normal sera tested, depresses the bactericidal activity against S. typhosa O 901 cells and also interferes with the adsorption of the antibodies responsible for sensitization of S. typhosa O 901 cells to cells of antigenically related, apparently S-state, Salmonella species. It has been suggested that the inhibiting factor may be an antibody specific for an antigen which is prominent in determining the antigenic characteristics of the surface of R-state cells, but is also present, though less prominently, on the surface of apparently S-state Salmonella cells.

Footnotes

¹ Thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Washington University, St. Louis, Missouri.

² Current address: Department of Medicine, Harvard Medical School, Boston, Mass.