HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fink, M. A. Articles by Quinn, V. A. Search for Related Content PubMed PubMed Citation Articles by Fink, M. A. Articles by Quinn, V. A.

Antibody Production in Inbred Strains of Mice¹

From the Department of Microbiology, University of Colorado School of Medicine, Denver, Colorado and the Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine

Abstract

1. Based on tests involving the use of 5 inbred strains of mice, evidence is presented which indicates that there is genetic variation in the ability of the mouse to produce demonstrable circulating antibody to either egg albumin or pneumococcus polysaccharide.

2. From the results obtained by the use of the two chemically definable antigens, it is suggested that the mouse does not form antibody to antigens of different chemical constitution in an identical manner.

3. Intra-abdominal injection of egg albumin incited the production of more antibody than intramuscular injection. The number of injections of polysaccharide—either 1 or 5—had no significant effect on antibody production.

4. The age of the animals had a highly significant effect on antibody production, animals 2 months old producing much less than animals 4 to 5 months old. The sex of the animals had no effect.

Footnotes

¹ This work was done in part under a Grant-in-Aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council.

This article has been cited by other articles:

				A. O. Vladutiu and N. R. Rose Autoimmune Murine Thyroiditis Relation to Histocompatibility (H-2) Type Science, December 10, 1971; 174(4014): 1137 - 1139. [Abstract] [PDF]

				N. M. Vaz and B. B. Levine Immune Responses of Inbred Mice to Repeated Low Doses of Antigen: Relationship to Histocompatibility (H-2) Type Science, May 15, 1970; 168(3933): 852 - 854. [Abstract] [PDF]

				W. K. Silvers and R. E. Billingham Genetic Background and Expressivity of Histocompatibility Genes Science, October 6, 1967; 158(3797): 118 - 119. [Abstract] [PDF]

				P. R. B. McMaster, E. M. Lerner II, and P. S. Mueller Genetic Influence on Experimental Allergic Thyroiditis in Guinea Pigs Science, January 8, 1965; 147(3654): 157 - 158. [Abstract] [PDF]

				H. Baer and R. T. Bowser Antibody Production and Development of Contact Skin Sensitivity in Guinea Pigs of Various Ages Science, June 14, 1963; 140(3572): 1211 - 1212. [Abstract] [PDF]

				J. Lederberg Genes and Antibodies: Do antigens bear instructions for antibody specificity or do they select cell lines that arise by mutation? Science, June 19, 1959; 129(3364): 1649 - 1653. [PDF]