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The Production of Antibody by Patients with Acute Viral Hepatitis¹

From the 98th General Hospital, Munich, Germany and the Jefferson Medical College, Philadelphia

Abstract

1. The amounts of antitoxin produced by 34 Schick-negative patients with acute viral hepatitis and 31 Schick-negative, essentially normal controls following the intramuscular injection of 50 Lf purified diphtheria toxoid were measured by titration in the skin of rabbits.

2. The pre-Schick levels of circulating antitoxin were, on the average, significantly greater in the patients with acute hepatitis, but there was no significant difference between the subsequent qualitative pattern of production of antibody or the intensity of immunologic response of the two groups.

3. There was no apparent relationship between the amounts of antitoxin produced and the age, severity of disease, or stage of disease in which toxoid was injected.

Footnotes

¹ This investigation was conducted under the sponsorship of the Commission on Virus and Rickettsial Diseases, Armed Forces Epidemiological Board, and was supported, in part, by the Office of The Surgeon General, Department of the Army, Washington, D. C.

The authors wish to express their appreciation for the assistance of Capt. Alfred S. Evans, MC, and Lt. Col. Helmuth Sprinz, MC, 98th General Hospital, Munich, Germany.

² Present address: Mayo Clinic, Rochester, Minn.