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Studies in Specific Hypersensitiveness

V. The Preparation of Fluid Extracts and Solutions for Use in the Diagnosis and Treatment of the Allergies with Notes on the Collection of Pollens

From the Department of Bacteriology and Immunology, Division of Immunology, in Cornell University Medical College and the New York Hospital

Abstract

From the beginning of his work upon the diagnosis and specific treatment of the allergies (hay fever, asthma, the urticarias), Robert A. Cooke (1, 2) has employed for both the diagnostic and therapeutic injections, fluid extracts of the various materials containing the exciting agents of these conditions. These extracts were originally made with physiological salt solution to which was added the usual percentage of carbolic acid. The preparations were standardized according to their nitrogen content. Cooke and also Cooke and Vander Veer, and Vander Veer, have reported their successes in the use of these extracts as diagnostic and therapeutic preparations At the time when these investigators became associated with the writer in the organization that has been established in the New York Hospital for the diagnosis and treatment of the allergies, some of the extracts that had been in use were subject to certain disadvantages.