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Studies in Specific Hypersensitiveness

III. On Constitutional Reactions: the Dangers of the Diagnostic Cutaneous Test and Therapeutic Injection of Allergens

From the Department of Bacteriology and Immunology, Division of Immunology in Cornell University Medical College, and the First Medical Division in the New York Hospital

Abstract

Definition of the Term. The term constitutional or general reaction is used to designate the group of symptoms occurring in allergic individuals after the absorption of an allergen and its transportation by the blood and lymph into the systemic circulation. Symptoms therefore occur in various organs and tissues affected by the allergen and may be protean in nature, since they depend upon the structures involved, which may differ with the individual and the allergen concerned. Such reactions may take place when the allergen is introduced through unnatural channels, as in the diagnostic skin test, subcutaneous or intravenous injection, or through natural channels, as after ingestion.

Data Used The data for the present paper are obtained more especially from a statistical study of 578 consecutive cases observed in 1920 and somewhat more generally from a personal experience over a period of ten years in the diagnosis and treatment of some four thousand allergic cases.

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