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Studies on Immunization Against Plague

IV. The Method of the Hemagglutination Test and Some Orservations on the Antigen¹

From the George Williams Hooper Foundation, University of California, San Francisco

Abstract

A hemagglutination test has been developed for P. pestis. The antigen is contained in old broth cultures, in extracts of killed and dried organisms and in alcohol-precipitated envelope antigens, but not in the protein fractions soluble in 0.25 saturation of ammonium sulfate solution or in those isolated by precipitation of soluble extracts by 0.3 or more saturated ammonium sulfate. The crude antigen has a low nitrogen content and is likely to be a polysaccharide.

The use of the hemagglutination test or of the inhibition of hemagglutination may be valuable in ascertaining the identity of plague antigens. The hemagglutination antigen appears not to play an important role as a protective antigen in plague.

Footnotes

¹ This work was sponsored by the Commission on Immunization, Armed Forces Epidemiological Board, and supported in part by the Office of the Surgeon-General, Dept. of the Army, Washington, D. C.