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The Effect of Certain Chemical Compounds on the Multiplication of T₂ Bacteriophage

From the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Public Health Service, Federal Security Agency, Bethesda 14, Maryland

Abstract

Bacteriophages offer a comparatively simple means of studying the effect of chemical compounds on the multiplication of viruses. Many substances have been found capable of inhibiting the development of bacteriophages without greatly affecting the multiplication of the host-cells (1–5). Certain metabolic poisons have been shown to inhibit phage multiplication in the absence of cell growth (6), while others do not. 5-Methyltryptophan (7) has been shown to inhibit the multiplication of T₂ bacteriophage, but only at levels that interfere with the growth of the host-cells. We have reported (8) that the multiplication of T₂ bacteriophage can be inhibited by desoxypyridoxine. The inhibition is reversed by pyridoxine and by glucose-6-phosphate or several other intermediates of carbohydrate metabolism, and by acetic acid or several other short-chain fatty acids.

This report is on the effect of 316 chemical compounds which were selected for testing on the multiplication of T₂ Escherichia coli bacteriophage.¹

Footnotes

¹ We wish to express our sincere appreciation to the following for supplying us with generous amounts of compounds to be studied: Drs. H. Bauer, B. L. Horecker, E. L. May, and L. F. Small, and the Malarial Testing Laboratory, all of the National Institutes of Health; Drs. G. B. Bachman, N. L. Drake, L. F. Fieser, T. D. Fontaine, R. P. Mariella, J. W. Mitchell, and M. S. Newman; Abbott Laboratories, Alrose Chemical Co., American Chemical Paint Co., Ciba Pharmaceutical Products, Inc., Dow Chemical Co., B. F. Goodrich Chemical Co., Heyden Chemical Corp., Hoffmann-LaRoche, Inc., the Institute of Textile Technology, Jefferson Chemical Co., Lederle Laboratories, Inc., Merck and Co., Monsanto Chemical Co., National Drug Co., Parke Davis and Co., Pyridium Corp., Remington Rand, Inc., Sharp and Dohme, Tennessee Eastman Corp., The Upjohn Co., Wallace and Tiernan Products, Inc., the National Research Council, and the Fish and Wildlife Service, U. S. Dept. of Interior.