HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by McGhee, R. B. Search for Related Content PubMed PubMed Citation Articles by McGhee, R. B.

The Effect of a Malaria Infection on the Titer of Complement and its Components in Ducks

From the Laboratories of the Rockefeller Institute for Medical Research New York 21, N. Y.

Abstract

Using duck serum in the preparation of test reagents, it was possible to determine the titers of components of duck complement. In uninfected animals the average titers of complement and its components were as follows: C' – 40, C'1 – 1080, C'2 – 100, C'3 – 90, C'4 – 180. In ducks undergoing infections with Plasmodium lophurae there was a reduction in C' and in all components. The presence of an in vivo hemolysis was always coincident with a decrease in C' and affected all components on the terminal day of infection. In subterminal hemolysis C'1 and C'3 were little affected in most instances, while C'2 and C'4 were sharply reduced. The drop in complement, the hemolytic reaction, and the destruction of parasites strongly suggest the intense antigen-antibody combination of acquired immunity.