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The Tuberculin Reaction. V. The Antigenicity of Chloroform Soluble Tuberculoprotein Wax¹

From the Department of Microbiology, University of Washington School of Medicine, Seattle, Washington

Abstract

Chloroform soluble tuberculoprotein wax in mineral oil is capable of inducing strong and typical tuberculin sensitivity in guinea pigs as judged by cutaneous, systemic and corneal reactions to Old Tuberculin.

The "defatting" of tubercle bacilli markedly reduces their capacity to produce tuberculin sensitivity but enhances their capacity to produce anaphylactic sensitivity to tuberculoprotein.

Footnotes

¹ This investigation was supported by a grant from the Division of Research Grants and Fellowships of the National Institutes of Health, U. S. Public Health Service.