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A Study of Infections Caused by Mumps and Newcastle Disease Viruses. II. Some Properties of Specific and Non-Specific Serum Hemagglutination Inhibitor Components

From the Departments of Pediatrics and Bacteriology, and the Hixon Memorial Laboratory, University of Kansas School of Medicine, Kansas City, Kansas

Abstract

1. A component present in serums obtained from apparently healthy human beings and rhesus monkeys inhibits hemagglutination of chicken erythrocytes by mumps and Newcastle disease (ND) viruses. A similar non-specific component, which undergoes fluctuation, occurs in serums of human beings convalescent from mumps parotitis and of monkeys infected with mumps or ND viruses. Specific serum-inhibitor substance, also present following infections from these viruses, is stable. Non-specific inhibitor is partially inactivated at 62 C for thirty minutes. It may be inactivated or destroyed by acetone, chloroform, trypsin, papain, and sodium periodate.

2. These data, among others, provide further evidence that the cross-reactions observed in hemagglutination-inhibition reactions with mumps and ND viruses and serums obtained from human beings convalescent from mumps parotitis cannot be due to corresponding antigens shared in common by these viruses.