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The Effect of Thorotrast on the Removal of Bacteria in the Splanchnic Area of the Intact Animal^*

From the Department of Medicine, the Department of Bacteriology and the Division of Dermatology and Syphilology, Duke University School of Medicine, Durham, North Carolina

Abstract

1. By a method of continuous intravenous infusion of bacteria combined with hepatic venous catheterization, the removal of bacteria from the blood circulating into the splanchnic area of the intact rabbit has been quantitated.

2. The interference of thorotrast with the subsequent removal of Micrococcus aureus from the blood stream of the rabbit is maximal 19 to 24 hours after the administration of thorotrast.

3. The mechanism by which thorotrast produces its blocking effect remains obscure.

Footnotes

^* Aided by the Duke University Research Council and The Anna H. Hanes Memorial Fund.

¹ Markle Scholar in Medicine.