HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Smolens, J. Articles by Warner, H. F. Search for Related Content PubMed PubMed Citation Articles by Smolens, J. Articles by Warner, H. F.

Immunogenic and Chemical Properties of Fractions Prepared from Ten Types of Group A Streptococci

From the Wyeth Institute of Applied Biochemistry, The Children's Hospital of Philadelphia, the Department of Pediatrics, School of Medicine, University of Pennsylvania and the Department of Medicine, School of Medicine, Temple University, Philadelphia, Pa.

Abstract

Fractions of low toxicity have been prepared from 10 types of group A streptococci. Small amounts of these fractions confer active protection in mice against 100 to 1000 average lethal doses of homologous bacterial challenge. Passive protection in mice is demonstrated by rabbit antiserum to type 3 fraction.

The Dick reaction in 6 out of 10 human beings changed from positive to negative after 3 injections of type 3 fraction totalling 155 mg. Pooled sera of certain individuals after immunization with type 3 fraction, showed passive protection in mice.

Chemical analyses show that the ribonucleic acid appears to be distributed uniformly in both the cytoplasm and in the surface of the streptococcal cell, whereas the desoxyribonucleic acid is present in higher concentration in the surface.

Footnotes

¹ Present address, The Children's Hospital of Philadelphia.