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Analysis of Immunity in Experimental Tsutsugamushi Disease

From the Department of Bacteriology, Chiba University School of Medicine, Chiba, Japan

Abstract

1. Mice, initially immunized with active rickettsiae and resistant to subsequent inoculation, could not withstand invasion of reinoculated rickettsiae into tissues: that is to say, superinfection is possible in experimental Tsutsugamushi disease.

2. Superinfection occurs whether doses of rickettsiae as large as 10⁵ LD₅₀ or as small as 10 LD₅₀ are used. Reinoculated rickettsiae invade immunized tissues, and persist longer than 180 days.