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Concurrent Infection with Influenza A and B Viruses in a Single Epidemic of Influenza

From the Hospital of The Rockefeller Institute for Medical Research, New York, N. Y. and Irvington House, Irvington-on-Hudson, N. Y.

Abstract

1. Investigation of an influenza epidemic in a children's institution disclosed concurrent infection of the population with both influenza A virus and influenza B virus. Individuals of the population were found to have been infected with influenza A virus, with influenza B virus, or with both viruses.

2. The availability of pre-epidemic sera from the entire population made it possible to determine the actual incidence of inapparent infection during an influenza outbreak; clinically inapparent infections occurred in 8% of the population.

3. Collateral studies with hamsters established that a mammalian host may be simultaneously infected with influenza A and B viruses and develop antibodies against both viruses, although the degree of antibody response may be less than that resulting from infection with either virus alone.