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Studies on the Chemotherapy of Vaccinia Virus

II. The Activity of Some Thiosemicarbazones

From the Squibb Institute for Medical Research, New Brunswick, New Jersey

Abstract

A series of thiosemicarbazones were studied for antivaccinial activity in chick embryos and in mice. Of those studied, benzaldehyde, 3-thiosemicarbazone, its p-acetamido, p-amino, p-methoxy, p-propoxy and p-ethylsulfonyl analogs were the most effective against vaccinia in chick embryos.

In mice infected intranasally with vaccinia, benzaldehyde, 3-thiosemicarbazone, its p-acetamido analog and the N⁴ isobutyl derivatives of these two compounds were the most effective, but only at doses near the maximal tolerated dose administered in the diet two days prior to infection and for ten days after infection.