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Alternate Passage of Influenza Virus. A Comparison of the Effects of Serial Passage and Alternate Passage of Type B Influenza Virus in Hamsters¹

From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor, Michigan

Abstract

The effects of alternate passage in eggs and hamsters on the adaptation of a strain of type B influenza virus to hamsters have been described. The pathogenicity for hamsters of virus passaged in this manner was maintained and appeared to be somewhat enhanced, but the line of virus did not become adapted to hamsters. On the contrary, the process of adaptation appeared to be retarded following a number of alternate passages in eggs and hamsters. The implication of these findings with respect to the phenomenon of adaptation has been discussed.

Footnotes

¹ This investigation was conducted under the auspices of the Commission on Influenza, Armed Forces Epidemiological Board, Office of the Surgeon General, U. S. Army, Washington, D. C.