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Mixed Infection with Bacterial Virus T5 and its Heat Stable Mutant^*

From the Department of Microbiology, New York University College of Medicine and College of Dentistry, New York

Abstract

It has been demonstrated that a majority of bacteria which have adsorbed at least one T5st⁺ particle and one T5st particle liberate both kinds on lysis. This finding provides independent evidence that more than one particle of T5 phage can take part in the infectious process in a single bacterium and is in agreement with Luria's conclusion that "multiplicity reactivation" of ultraviolet-inactivated T5 phage indicates that more than one phage particle can take part in the infectious process.

The average burst size of the mixedly infected bacteria is the same as that of bacteria infected with either phage type alone indicating that there is no depressor effect with this pair of viruses.

Footnotes

^* Aided by a grnt from the National Foundation for Infantile Paralysis, Inc.