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Serological Reactiosn in Rheumatoid Arthritis

III. Increased Agglutination of Sersitized Sheep Erythrocytes in the Presence of Normal Animal Sera^*

From the Department of Bacteriology and Immunology,and the Department of medicine, Southwestern Medical School of the University of Texas, Dallas, Texas

Abstract

1. Samples of serum from 7 species of normal animals were found to increase the agglutination of sheep erythrocytes by rabbit anti-sheep-cell serum.

2. Sheep, goat, guinea pig, and horse sera gave mean differential titers above the range found with normal human sera. No samples of animal serum were found, however, which agglutinated sensitized sheep cells in dilutions as high as those often observed for serum from patients with rheumatoid arthritis.

3. Normal human serum in low dilutions increased the sheep-cell agglutinin titer of rabbit anti-sheep-cell serum and infectious-monunucleosis serum, but did not similarly affect the titer of serum from normal persons or from individuals with serum sickness.

4. Horse serum, goat serum and rheumatoid-arthritis serum, in appropriate dilutions, increased the titer of rabbit anti-sheep-cell serum but did not significantly enhance agglutination by normal human serum or by serum from persons with infectious monunucleosis or serum sickness.

5. Rheumatoid-arthritis serum did not increase the agglutination of sheep cells by bean extract.

Footnotes

^* Aided in part by grants from the Lederle Laboratories Division of the American Cyanamid Company, Pearl River, N. Y., and the Rose Lampert Graff Foundation, Los Angeles, California.