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Comparison of Seven Antibiotics against Hemophilus Pertussis Infection in Chick Embryos¹

Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital and the Department of Medicine, Harvard Medical School, Boston, Mass.

Abstract

Seven antibiotics were tested for their effect on a lethal Hemophilus pertussis infection in embryonated hens' eggs. Suitable doses of all these antibiotics produced significant prolongation of life of the embryos and survival of a large proportion of them for 10 days. There was wide variation among the agents in the degree of protection obtained from the different doses used. The comparative effectiveness of the different antibiotics depends to some extent on the criterion used as the basis of comparison. The complete elimination of viable organisms from the host was not regularly accomplished by any of the agents under the conditions of these experiments.

Footnotes

¹ Aided by a grant from the United States Public Health Service.