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A Non-Pathogenic Bartonella-Like Organism Developing in Embryonate Eggs after Injection with Haemobartonella Muris¹

From the Departments of Bacteriology, Pathology and Biology, St. Louis University, St. Louis, Missouri

Abstract

An organism morphologically indistinguishable from Haemobartonella muris and H. tyzzeri has been cultivated in embryonate eggs after inoculation with rat blood infected with H. muris. Subculture on complex cell-free media was obtained, but primary isolation on these media could not be achieved.

The organism is an intracellular parasite forming compact spherical cytoplasmic clusters which are identical with those produced by Bartonella bacilliformis and H. tyzzeri and are believed to be almost specific for organisms of this group. Further characteristics supporting the view that the organism is H. muris are growth in fused clumps in cell-free media and inability to ferment carbohydrates.

Injection into splenectomized bartonella-free rats resulted in no clinical or hematological evidence of haemobartonellosis and gave no immunity to subsequent infection with H. muris. For this reason, positive identification of the organism cannot be made at present.

Footnotes

¹ This work was supported in part by a Grant-in-Aid from the Research Grants Division of the National Institutes of Health, U. S. Public Health Service.

² This paper is submitted as partial fulfilment of the requirements for the degree of Doctor of Philosophy, St. Louis University.