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Biophysical Studies of Blood Plasma Proteins. XIII

Analysis of Immunological Heterogeneity of Human Gamma Globulin Fractions¹

From the Department of Microbiology, New York University College of Medicine, New York, N. Y. and the Departments of Physiological Chemistry and Chemistry, University of Wisconsin, Madison, Wis.

Abstract

Four -globulin fractions of human serum which differ slightly in average electrophoretic mobility at pH 8.6 have been investigated by physical and immunochemical methods. Each preparation consists of several antigens, and the quantitative immunological behavior of each fraction is determined by the relative proportions of the various components present. The difficulties involved in using immunological methods for assay of -globulin in body fluids are discussed. The various fractions differ from one another most strikingly in the region of antigen excess.

Footnotes

¹ This work was supported in part by grants from the United States Public Health Service and the Wisconsin Alumni Research Foundation.

² William Hallock Park Fellow, New York University 1948–1949.

³ U. S. Public Health Fellow.

This article has been cited by other articles:

				J. R. Cann, R. A. Brown, S. J. Singer, J. B. Shumaker Jr., and J. G. Kirkwood Ultracentrifugal Studies of ggr-Globulins Prepared by Electrophoresis-Convection Science, July 13, 1951; 114(2950): 30 - 33. [PDF]