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Studies in Dysentery Vaccination

VIII. Comparative Response and Persistence of Immunity in Mice Vaccinated Intraäbdominally or by Gavage with Shigella Sonnei^*

Children's Hospital Research Foundation and The Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio

Abstract

Mice, which had been vaccinated intraäbdominally with one dose of 100 million Shigella sonnei as a broth vaccine, showed a very high degree of immunity against intraäbdominal challenge one week after vaccination. Immunity decreased over the following 12 weeks but was still high at the end of that time.

Mice, which were vaccinated by gavage with 15 daily doses of one billion Sh. sonnei as broth vaccine, did not develop as high a degree of immunity against intraäbdominal challenge as did the mice vaccinated intraäbdominally. This immunity decreased rapidly within a 12 week period.

Sera from mice vaccinated intraäbdominally showed a high degree of passive mouse protective power and low agglutinative titers. Sera from mice vaccinated by gavage showed a significant but lesser degree of passive mouse protective power and absence of agglutinins.

Footnotes

^* This study was conducted under a grant-in-aid from the U. S. Public Health Service.