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Serological Reactions in Rheumatoid Arthritis

I. Factors Affecting the Agglutination of Sensitized Sheep Erythrocytes in Rheumatoid-Arthritis Serum¹

Department of Bacteriology and Immunology, and the Department of Medicine, Southwestern Medical School of the University of Texas, Dallas, Texas

Abstract

Methods of demonstrating the effect of serum from patients with rheumatoid arthritis on the agglutination of sheep erythrocytes by small amounts of rabbit antisheep-cell serum are described and the influence of certain factors on the reaction is indicated. The degree of agglutination obtained is dependent upon the concentration of antisheep-cell antibody, which should be standardized for this test on the basis of its agglutinating rather than its hemolytic capacity. The property of rheumatoid-arthritis serum affecting the agglutination of sensitized sheep cells was found to be stable on storage for several months.

Footnotes

¹ The work presented in this and the following paper was aided in part by grants from the Lederle Laboratories Division of the American Cyanamid Company, Pearl River, N. Y., and the Rose Lampert Graff Foundation, Los Angeles, California.