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Chemical and Immunological Properties of Diphtheria Toxoid Purified by Ammonium Sulfate Fractionation

Division of Biologic Laboratories, Massachusetts Department of Public Health, Forest Hills, Boston, Massachusetts

Abstract

1. A simple method for the purification of diphtheria toxoid has been presented.

2. The products have been evaluated with respect to purity, antigenicity, and stability.

3. Preparations having a purity in excess of 2000 Lf per mg N have been obtained.

4. Evidence has been presented which indicates that the antigenicity per Lf increases with the purity of the toxoids studied.

5. A linear logarithmic relationship between the flocculation time and titer at the toxoid-antitoxin equivalence point has been shown.

6. Various relations between Lf, Kf, purity, and antigenicity have been studied.

Footnotes

¹ Present address: Boston University School of Medicine, Boston 18, Mass.