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Studies on Pathogenesis and Immunity in Tularemia

III. Immunogenic Properties for the White Mouse of Various Strains of Bacterium Tularense

From the Department of Bacteriology, University of Kansas, Lawrence

Abstract

1. Living organisms of certain strains of Bacterium tularense were found to elicit a high degree of immunity in white mice when inoculated in sublethal concentrations.

2. Killed vaccines gave markedly less protection in proportion to the amount of antigen injected than was obtained with living vaccines.

3. Strains of low virulence multiplied following their inoculation into white mice, but decreased progressively after the fourth or fifth day until none could be demonstrated in spleen, liver and heart blood on or about the 15th day.

4. Mice immunized with a number of strains of lowered virulence were highly resistant to infection with virulent strains and disposed of the organisms very rapidly.

5. As few as 20 living cells of the Jap strain produced a good immunity when inoculated into white mice.

6. Vaccination of white mice with living Jap cells produced a high degree of immunity within three days following inoculation.

7. The Jap strain of Bact. tularense provided white mice with an immunity against more than one virulent strain.

Footnotes

^* Offered in partial fulfillment for the degree of Doctor of Philosophy

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