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Tudies on Pathogenesis and Immunity in Tularemia

II. Immune Response of the White Rat to Bacterium Tularense

From the Department of Bacteriology, University of Kansas, Lawrence

Abstract

1. The agglutinin response in rats vaccinated against Bact. tularense is very rapid and the initial rise parallels roughly the time at which immunity to infection develops.

2. The agglutinin titer in vaccinated, recovered and normal rats after infection, rises rapidly and continues at a high level for a longer period than after vaccination.

3. A high degree of active immunity after vaccination of the rat was found to persist for as long as 99 days whereas a high titer of agglutinins persisted for only 11 to 17 days.

4. Rats are more solidly immune after recovery from infection than after vaccination with killed cultures. This immunity also persists at a high level for at least 114 days.

5. Normal, vaccinated and recovered rats were shown to harbor living organisms in the spleen for 31 to 46 days after infection.

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