HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Downs, C. M. Articles by Edgar, E. P. Search for Related Content PubMed PubMed Citation Articles by Downs, C. M. Articles by Edgar, E. P.

Studies on Pathogenesis and Immunity in Tularemia

I. The Pathogenesis of Tularemia in the White Rat

From the Department of Bacteriology, University of Kansas, Lawrence

Abstract

1. The invasion and multiplication of Bacterium tularense has been followed quantitatively after inoculation of the virulent organisms in normal, vaccinated and recovered white rats.

2. Virulent Bact. tularense spread by the usual lymphogenic and hematogenic routes in normal, vaccinated or recovered white rats.

3. Rats immunized by vaccination with killed cultures or by recovery from a previous sublethal infection are able to limit the net increase of virulent organisms and to sterilize their tissues.

4. The routes of spread and the increase of organisms in immune animals differ only in a quantitative fashion from those observed in normal animals.

5. Recovered rats are more solidly immune than vaccinated animals, as indicated by the smaller number of organisms recovered from the tissues and by their lower mortality rate after multiple lethal doses of virulent organisms.

6. The behavior of avirulent strains in normal, vaccinated and recovered animals varies in degree but not in kind from virulent strains.

This article has been cited by other articles:

				C. RICK LYONS and T. H. WU Animal Models of Francisella tularensis Infection Ann. N.Y. Acad. Sci., June 1, 2007; 1105(1): 238 - 265. [Abstract] [Full Text] [PDF]