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Multiplication of Pneumonia Virus of Mice (PVM) in the Rabbit Lung and the Demonstration of a Hemagglutinating Component in Lung Suspensions from Normal Animals

From the Hospital of The Rockefeller Institute for Medical Research

Abstract

Multiplication of PVM in the rabbit lung after intratracheal inoculation has been demonstrated. The virus was maintained through eleven serial passages in rabbit lungs. The development of a hemagglutinating component (RHC) in heated suspensions of rabbit lungs upon prolonged storage at 4 C is described and various properties of the component are enumerated. There is a close similarity between the hemagglutination reactions of RHC and PVM. The differences between RHC and hemagglutinating components previously found in other animal tissues are discussed. The available evidence suggests that RHC is a complex substance of large size which contains phospholipid and indicates that the lipid is essential for hemagglutinating activity.

Footnotes

¹ Fellow in the Field of Virus Diseases of the National Research Council.