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The Immunologic Reactivity of Bovine Serum Albumin Labelled with Trace-Amounts of Radioactive Iodine(I¹³¹)¹

From the Departments of Medicine and Chemistry, New York University College of Medicine, New York 16, New York

Abstract

In vitro studies have been carried out with bovine serum albumin which was tagged with radioactive iodine (I¹³¹) by direct iodination or by coupling with radioactive p-iodophenyldiazonium chloride. The tagged proteins proved capable of determining relative antibody concentrations in antisera for the native protein. Antisera directed against native bovine serum albumin did not here distinguish a tagged bovine serum albumin preparation from native bovine serum albumin in quantitative precipitin studies.

Footnotes

¹ Presented before the Federation of American Societies for Experimental Biology, April, 1948 (1).

² Investigation conducted during tenure of a Senior Research Fellowship of the National Institute of Health.