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Studies on the Chemotherapy of Virus Infections

I. General Anesthetics and Other Drugs Ineffective Against Experimental Virus Infections in Mice

From The Jack and Heintz Laboratory, The Department of Contagious Diseases, City Hospital and The Department of Pediatrics, Western Reserve University, Cleveland, Ohio

Abstract

Groups of mice inoculated with 2 to 4 LD 50 doses of Eastern equine, Western equine, St. Louis encephalitis, poliomyelitis or influenza viruses and treated with maximal non-fatal doses of diethyl ether by inhalation, sodium amytal, paraldehyde, avertin, magnesium sulfate, morphine, Cytochrome C, dithiobiuret or dithiocarbamate, prior to and following inoculation with the viruses, showed no alteration in the courses of the ensuing infections.

The theoretical reasons for the use of these compounds in attempts at chemotherapy of virus infections are discussed.

Footnotes

^* Present address, U. S. Public Health Service, C. D. C. Virus & Rickettsia Branch Route 3, Box 436 Montgomery, Ala.

¹ Research Resident, 1946–47.

² Visiting Fellow, 1946–47. Present address, Tientsin Central Hospital, Tientsin, China.