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A Quantitative Study of Passive Anaphylaxis in the Guinea Pig

V. The Latent Period in Passive Anaphylaxis in Its Relation to the Dose of Rabbit Antiovalbumin¹

From the Departments of Neurology and Bacteriology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York

Abstract

1. The latent period for passive anaphylactic sensitization in the guinea pig was investigated with known amounts of rabbit antiovalbumin and was found to be a function of the amount of antibody used, when a constant amount of antigen is used which is sufficient to react completely with the antibody injected.

2. The proportions of antibody and antigen required for fatal shock varied at different time intervals between sensitization and shock.

Footnotes

¹ Aided by grants from the National Multiple Selerosis Society and the William J. Matheson Commission.