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The Solubility of Equine Tetanal Antitoxin in Methanol-Water Mixtures of Controlled pH, Ionic-Strength and Temperature^*

From the Institute of Pathology, Western Reserve University, Cleveland 6, Ohio

Abstract

The solubility of equine tetanal antitoxin in methanol-water mixtures of controlled pH, ionic strength, and temperature has been determined.

On the basis of these determinations, three steps have been developed for the separation of tetanal antitoxin from other protein components of plasma. The relatively high ionic strength (0.2) at pH 5 and 10 per cent methanol which is employed in the second step contributes most to this separation.

Footnotes

^* Taken in part from a thesis submitted by Ruth G. Wittler in partial fulfillment of the requirements for the Degree of Doctor of Philosophy.