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The Family Relationship of Encephalomyocarditis, Columbia-SK, M. M., and Mengo Encephalomyelitis Viruses

From the Department of Virus and Rickettsial Diseases, Army Medical Department Research and Graduate School, Army Medical Center, Washington 12, D. C.

Abstract

By means of neutralization, complement-fixation, and cross-immunity tests, the viruses known as encephalomyocarditis, Columbia-SK, M. M., and Mengo encephalomyelitis have been found to be identical.

Analysis of their known physical and pathogenic properties further indicates that they are probably different strains of a single virus.

We have been unable to demonstrate any relationship between the four strains of this virus and the Lansing, Yale-SK and Brunhilde strains of poliomyelitis or a murine encephalomyelitis virus.