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Prophylactic Use of Schistosomal Antigen

Department of Pharmacology, Woman's Medical College of Pennsylvania, Philadelphia, Pa.^1,2,

Abstract

The administration of a Schistosoma mansoni antigen, prepared from adult worms to mice, before exposing the mice to 10 cercariae each, was associated to a statistically significant degree with a reduction in the number of cercariae which developed into adult worms.

2. There was no evidence that the antigen had a marked effect, if any, on rate of development; nor that one sex was more susceptible; nor that the localization of the worm was affected.

Footnotes

¹ The experimental work reported here was completed when the writer was a member of Department of Therapeutics, New York University, New York, N. Y., 1944–46.

² Present address: Department of Radiation Biology, School of Medicine and Dentistry, University of Rochester, Rochester 7, N. Y.