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Therapy of Experimental Brucella Infection in the Developing Chick Embryo^1,2,

IV. Therapy with Aureomycin

Abstract

Previous reports have described a method for the evaluation of therapeutic agents against experimental Brucella infection, utilizing the developing chick embryo (1, 2, 3). Data comparing the relative effectiveness of sulfadiazine and streptomycin, individually and in combination, against infections in the chick embryo with each of the three species of Brucella have shown a definite synergism of these two agents when administered together.

The early reports of Pulaski and Amspacher (4, 5), Eisele and McCullough (6), and those from this Clinic (7, 8), have demonstrated the marked advantage of combined therapy with streptomycin and sulfadiazine in human brucellosis over previous methods of therapy. But this form of treatment possesses certain disadvantages. Because streptomycin must be injected intramuscularly, and because the antibiotic is potentially toxic, hospitalization of patients is essential. In addition to the expense of treatment and the threat of toxic reactions, relapses have occurred following the cessation of treatment.

Footnotes

¹ From the Division of Internal Medicine, University of Minnesota Hospitals, and Medical School, Minneapolis.

² This investigation was supported by research grants from the Division of Research Grants and Fellowships of the National Institute of Health, U. S. Public Health Service; Committee on Scientific Research, American Medical Association; and the Lederle Laboratories.

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				W. W. SPINK, W. H. HALL, and R. MAGOFFIN FOLLOW-UP STUDY OF THERAPY IN FORTY-EIGHT CULTURALLY PROVED CASES OF BRUCELLOSIS: Streptomycin and Sulfadiazine, Aureomycin, and Chloramphenicol (Chloromycetin(R)) Arch Intern Med, October 1, 1951; 88(4): 419 - 432. [Abstract] [PDF]