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Influenza Vaccination: A Comparison of Antibody Response Obtained by Various Methods of Administration

From the Infectious Disease Laboratory of the San Francisco Hospital¹

Abstract

1. Two hundred and forty-three adults and children were inoculated by the subcutaneous or interadermal routes with the combined Type A and Type B influenza virus vaccine.

2. The rise in antibody in adults following intradermal inoculation, using 0.1 ml of vaccine, was comparable to that following subcutaneous inoculation of 0.1 ml.

3. In adults, two intradermal inoculations of 0.1 ml each, given three days apart, did not produce antibody-rises which were significantly greater than those following a single intradermal inoculation.

4. The antibody-rise in children, following two intradermal inoculations of 0.1 ml each, was somewhat greater than that following the same doses given subcutaneously.

Footnotes

¹ This laboratory is supported by the Divisions of Medicine and Pediatrics of the University of California Medical School and by the Department of Public Health of the City and County of San Francisco.