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Studies on the Etiology and Pathogenesis of Experimental Meningoencephalomyelitis in the Guinea Pig¹

From the Department of Pathology, Cornell University Medical College and The New York Hospital, New York City

Abstract

The etiological factor responsible for the demyelinizing meningoencephalomyelitis which occurs in guinea pigs following a single subcutaneous injection of a water-in-oil emulsion containing killed tubercle bacilli and brain is apparently a heat-stable, phosphatide-like material present in the white matter of the adult central nervous system. The active material does not seem to resemble any of the five previously described brain-haptens, except possibly the alcohol-soluble one. The mechanism of its action is not yet known, nor is the relation between the experimental disease and the various demyelinating diseases of man known, except perhaps for its similarity to the paralytic accidents following rabies vaccination.

Footnotes

¹ Aided by a grant from the United States Public Health Service.

² The able assistance of Mr. Robert H. Purnell, Cornell University Medical College, is gratefully acknowledged.