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Immunological Evidence on the Role of the Lymphocyte in Antibody Formation

From the Division of Infectious Diseases and Laboratory of Pathology, National Institute of Health, U. S. Public Health Service, Bethesda 14, Maryland

Abstract

In summary, it seems from the evidence here presented that the relatively high antibody content of lymph may be accounted for, at least in part, by physical transfer from blood. The ratio of lymph antibody to serum antibody increases when the node has been stimulated by an irritant such as a heterologous antigen. There is very little significant evidence in these experiments to indicate that the lymphocytes or lymph node cells per se carry large amounts of antibody. Until more critical immunological technics and better controlled experiments are employed, the immunological evidence for lymphocyte production of antibodies must be considered incomplete.

Footnotes

¹ Surgeon.

² Surgeon.

³ Senior assistant surgeon.

⁴ Biologist.

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				H. A. REIMANN INFECTIOUS DISEASES: Fifteenth Annual Review of Significant Publications Arch Intern Med, January 1, 1950; 85(1): 156 - 197. [Abstract] [PDF]