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Quantitative Studies in Anaphylaxis

III. Effect of the Alum Adjuvant and Route of Administration on the Sensitizing Dose¹

Abstract

Alum-precipitated ovalbumin had a sensitizing capacity in guinea-pigs of from 4 to nearly 400 times greater than that of ovalbumin in saline solution, depending upon the route of administration of the sensitizing dose.

For ovalbumin in saline solution the sensitizing capacity of the antigen by intraäbdominal administration was about 1 times greater than by intravenous injection and nearly 2 times greater that by subcutaneous administration. Only the latter difference was statistically significant.

For alum-precipitated ovalbumin the sensitizing capacity by subcutaneous administration was 2 times greater than by intraäbdominal administration and 60 times greater than by intravenous injection. Both of these differences were statistically significant.

Footnotes

¹ Contribution from Allergen Research Division, Bureau of Agricultural and Industrial Chemistry, Agricultural Research Administration, U. S. Department of Agriculture.