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The Journal of Immunology, 1949, 61: 95-105.
Copyright © 1949 by The American Association of Immunologists, Inc.
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The Effect of Complement in the Neutralization of Mumps Virus*

Glen R. Leymaster{dagger} and Thomas G. Ward

From the Department of Bacteriology, The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland

Abstract

Complement as a necessary component of antigen-antibody reactions has been extensively studied in bacterial and hemolytic systems (1, 2). There have been few studies of the role of complement in the neutralization of virus by immune sera, and these have yielded inconsistent results.

Gordon (3) in 1925, using vaccinia virus, studied the neutralizing effect of 3 immune sera. Heating reduced the neutralizing power of each serum. In only one of the 3 sera could the neutralizing effect be restored by the addition of fresh normal serum. In 1931, Mueller (4), testing neutralizing antibodies against Rous fowl sarcoma, showed that the inhibition of virus by immune serum could be enhanced with fresh normal guinea pig serum, and that the diminished titer of heated antiserum could be restored with fresh complement. Howitt (5) was unable to demonstrate any effect of complement on the neutralization of Western Equine Encephalomyelitis, and Sabin reported similar negative results with the vaccina virus (6).

Footnotes

* Supported in part by a grant from the Research Grants Division, National Institute of Health, United States Public Health Service.

{dagger} Present Address: Department of Public Health and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah.






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