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The Effect of Acriflavine and Phosphine GRN on Lysis of Bacteria by Bacteriophage^*

From the Department of Bacteriology, School of Medicine, University of Pennsylvania, Philadelphia 4, Pennsylvania

Abstract

1. The specificity of two acridine compounds in inhibiting lysis by bacteriophage was shown in the reaction of four bacteria-bacteriophage systems to their presence.

2. The phage-inhibiting effect of one of these compounds, acriflavine, was effectively neutralized by yeast nucleic acid, riboflavin, thiamin, nicotinamide and sodium lauryl sulfate. This is in contrast to the work of Fitzgerald and Lee (6) with phosphine GRN where only yeast nucleic acid was found to be effective.

Footnotes

^* This study was aided by a grant from the United States Public Health Service.